Suchergebnisse

AbstractIntroductionSkin cancer affecting the nail unit is rare but is associated with morbidity, and melanoma has a high mortality rate. The principal treatment is surgical excision and methods can be classified into digit‐sparing surgery or amputation. Digit‐sparing surgery (wide excision or Mohs surgery) may be safe and effective for malignancies involving the nail unit in comparison to amputation if there is not bony invasion. The objective was to assess the efficacy and safety of different methods of surgical excision for skin cancer involving the nail unit.MethodsProspective comparative studies (randomized controlled studies, non‐randomized controlled studies and prospective observational studies) of surgical excision for skin cancer of the nail unit in all participants were eligible for inclusion. We searched electronic databases, trials registers and conference abstracts. We checked the reference lists of included studies and related systematic reviews for further references to relevant studies, and we contacted experts to enquire if they were aware of any additional relevant trials. We used standard methodological procedures expected by Cochrane. The primary outcomes were overall survival, disease free survival and adverse events/outcomes at 30 days. The secondary outcomes were quality of life outcomes. We planned to use GRADE to assess the quality of the evidence for each outcome.ResultsWe did not identify any studies that met the inclusion criteria for this review. We have been unable to assess our outcomes of overall survival, disease free survival, adverse events/effects and quality of life.ConclusionsAs we have not identified any studies for inclusion, we are unable to assess the efficacy and safety of different methods of surgical excision for skin cancer involving the nail unit. We suggest that comprehensive cancer registry analysis is required in this field to obtain meaningful data.

Frontmatter -- Contents -- Preface -- Acknowledgements -- A Scottish Assembly -- Introduction -- Part I: Beginnings, 1968-74 -- Introduction -- The Claim of Scotland -- Why Enmity and Conflict? -- The Declaration of Perth -- The Three Dreams of Scottish Nationalism -- The Government of Scotland -- Forms and Consequences of Federalism -- An Assembly -- A Scheme of Legislative Devolution -- The New Appeal of Nationalism -- Part II: The Devolution Years, 1974-83 -- Introduction -- Scottish Government -- A Parliament for Scotland -- The Devolution of the Intellectuals -- Our Changing Democracy -- Nationalism, Community and Democracy -- Speech to Parliament -- The Slide to Independence -- The Trouble with John P. Mackintosh -- Why it must be 'No' when Assembly is put to the Vote -- The Conservative Party and Devolution -- Speech and Interview -- The Defeat of Devolution -- Interview: Portrait of a Devolutionist -- Part III: Reactions to Thatcherism, 1983-92 -- Introduction -- Interview: Devolution -- Scotland - Omega One -- Towards a Constitutional Convention -- The Devolution Maze -- A Claim of Right for Scotland -- Lecture -- Unrepentant Gradualism -- The Government of Scotland -- Church and Nation: a Catholic View -- Women's Issues and the Scottish Assembly -- Independence in Europe -- Thatcherism in a Cold Climate -- The Implications of a Scottish Parliament for Women's Organisations in Scotland -- The Scottish Constitutional Convention -- Part IV: Towards the Parliament, 1992-7 -- Introduction -- The Scottish Question -- Taking Stock of Taking Stock -- To Make the Parliament of Scotland a Model for Democracy -- The Governance of Scotland -- A Scottish Parliament: Friend or Foe to Local Government? -- Scottish Local Government in Europe -- Fundamentals for a New Scotland Act -- Scotland's Next Step -- Sovereignty after the Election -- Three-level Path to Flourish in Europe -- Scotland's Parliament -- What's the Story? -- Losing Sight of Tinkerbell -- Don't Wreck the Heritage we all Share -- Free, on our Own Terms -- Some Poetry, Pipers and Politics for the People -- References -- Index